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KMID : 0363320030240010084
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Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 1 p.84 ~ p.93
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Effects of the Sungjuchunggan-tang(Xingjiuqinggan-tang) on alcoholic metabolism and alcoholic liver damages
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Kim Jin-Sung
Park Seong-Kyu
Yoon Sang-Hyub
Ryu Bong-Ha
Ryu Ki-Won
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Abstract
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Objectives : The aim of this study was to investigate effects of the Sungjuchunggan-tang(Xingjiuqinggan-tang), which has been used for alcoholic diseases in Oriental medicine, on alcoholic metabolism and alcoholic liver damage.
Methods : We evaluated the activities of alcohol dehydrogenase(ADH)and aldehyde dehydrogenase(ALDH), and measured the levels of AST, ALT, glucose, triglyceride, HDL-cholesterol, LDL-cholesterol and phospholipid in serum of guinea pigs.
Results and Conclusions : In this experiment, Sungjuchunggan-tang, Pharbitidis Semen and Puerariae Radix significantly suppressed the activity of ADH which is a precursor enzyme of acetaldehyde. Sungjuchunggan-tang and Pharbitidis Semen significantly suppressed the activity of ALDH, which is a catabolic enzyme, and increased its level. Due to alcohol consumption, level of ALT and AST were significantly reduced.
These experimental results suggest that Sungjuchunggan-tang and Pharbitidis Semen inhibit the formation of acetaldehyde in the metabolism of alcohol, and affect the recovery of weakened liver functions caused by alcohol.
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KEYWORD
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Sungjuchunggan-tang(Xingjiuqinggan-tang), Pharbitidis Semen, Puerariae Radix, ADH, ALDH
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